Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | BCL2 | P10415 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 4/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837838 | 1.00 | GSTP1 (0.44) | GSTP1GSTM2KLK5CYP11B1CYP11B2 | |
| SCHEMBL503425 | 0.93 | GSTP1 (0.46) | GSTP1GSTM2KLK5CYP11B1CYP11B2 | |
| SCHEMBL9837445 | 0.85 | ITGA4 (0.42) | KLK5CYP11B1CYP11B2ACEFNTA | |
| SCHEMBL9837440 | 0.85 | ITGA4 (0.42) | KLK5CYP11B1CYP11B2ACEFNTA | |
| SCHEMBL8254417 | 0.82 | CYP11B1 (0.53) | KLK5CYP11B1CYP11B2PPARGPPARA | |
| Histidine SCHEMBL18301539 | 0.82 | GSTP1 (0.37) | GSTP1GSTM2KLK5BCL2PPARG | |
| Histidine SCHEMBL18301538 | 0.82 | GSTP1 (0.37) | GSTP1GSTM2KLK5BCL2PPARG | |
| SCHEMBL28058939 | 0.76 | ALDH1A1 (0.48) | CYP11B1CYP11B2ACEFNTAFNTB | |
| SCHEMBL16245923 | 0.76 | ALDH1A1 (0.48) | CYP11B1CYP11B2ACEFNTAFNTB | |
| SCHEMBL9838711 | 0.75 | TACR1 (0.50) | KLK5CYP11B1CYP11B2ACEFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245637-B1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| US-4816463-A | HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| US-4812462-A | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0245637-A1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |