SCHEMBL9837833

SCHEMBL9837833

O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)C(Cl)Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.50
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA5A P35218 1/20 0.37
CYP2D6 P10635 1/20 0.35
SRC P12931 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
USP2 O75604 1/20 0.35
GAA P10253 1/20 0.35
LMNA P02545 3/20 0.35
MAPK1 P28482 2/20 0.34
TRPA1 O75762 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9374946 0.85 HSP90AA1 (0.47) HSP90AA1ALDH1A1MEN1MAPTHPGD
SCHEMBL9476283 0.80 HSP90AA1 (0.50) HSP90AA1ALDH1A1MEN1MAPTHPGD
SCHEMBL9374953 0.77 HSP90AA1 (0.47) HSP90AA1ALDH1A1MEN1MAPTHTT
SCHEMBL1508 0.77 HSP90AA1 (0.55) HSP90AA1ALDH1A1MAPTKMT2ACA2
SCHEMBL814 0.76 HSP90AA1 (0.59) HSP90AA1ALDH1A1MEN1MAPTKMT2A
SCHEMBL7522374 0.76 HSP90AA1 (0.59) HSP90AA1ALDH1A1MEN1MAPTKMT2A
SCHEMBL2574392 0.76 HSP90AA1 (0.50) HSP90AA1ALDH1A1MEN1MAPTHTT
SCHEMBL7908281 0.73 HSP90AA1 (0.44) HSP90AA1ALDH1A1HTTSMN1; SMN2CA2
SCHEMBL7713573 0.73 L3MBTL1 (0.49) HSP90AA1ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL23757989 0.72 HSP90AA1 (0.55) HSP90AA1ALDH1A1MEN1KMT2ACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0154528-B1 ALKENE, ALKYNE OR CYCLOALKYLENE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-12-11 EP disclosed
EP-0154528-A2 Alkene, alkyne or cycloalkylene derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-09-11 EP disclosed