Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | LDLR | P01130 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837578 | 0.98 | NFE2L2 (0.47) | NFE2L2METAP1ESR1ESR2CYP19A1 | |
| SCHEMBL10488102 | 0.92 | NFE2L2 (0.39) | NFE2L2ESR1ESR2 | |
| SCHEMBL10378485 | 0.78 | NFE2L2 (0.49) | NFE2L2METAP1EPHX1EPHX2 | |
| SCHEMBL9838929 | 0.76 | KDM4E (0.40) | NFE2L2EPHX1GAA | |
| SCHEMBL9839149 | 0.76 | NFE2L2 (0.41) | NFE2L2ESR1ESR2 | |
| SCHEMBL10379530 | 0.76 | NFE2L2 (0.46) | NFE2L2METAP1EPHX1EPHX2 | |
| SCHEMBL10379522 | 0.75 | NFE2L2 (0.46) | NFE2L2METAP1LDLREPHX1EPHX2 | |
| SCHEMBL9838977 | 0.74 | KDM4E (0.38) | NFE2L2EPHX1GAA | |
| SCHEMBL10379313 | 0.74 | NFE2L2 (0.45) | NFE2L2METAP1ESR1ESR2LDLR | |
| SCHEMBL9838822 | 0.74 | NFE2L2 (0.39) | NFE2L2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | claimed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | claimed |
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |