Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838822 | 0.98 | NFE2L2 (0.39) | NFE2L2PDE4APRMT5WDR77ESR1 | |
| SCHEMBL10379784 | 0.77 | NPSR1 (0.39) | NFE2L2PDE4APRMT5WDR77MAPT | |
| SCHEMBL9838929 | 0.77 | KDM4E (0.40) | NFE2L2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9837901 | 0.76 | NFE2L2 (0.50) | NFE2L2ESR1ESR2 | |
| SCHEMBL9838977 | 0.75 | KDM4E (0.38) | NFE2L2KDM4ELMNA | |
| SCHEMBL9837578 | 0.74 | NFE2L2 (0.47) | NFE2L2ESR1ESR2SLC6A3 | |
| SCHEMBL10488102 | 0.70 | NFE2L2 (0.39) | NFE2L2ESR1ESR2 | |
| SCHEMBL16564175 | 0.70 | SLC6A4 (0.39) | SLC6A3KDM4EALDH1A1 | |
| SCHEMBL9837883 | 0.69 | NFE2L2 (0.39) | NFE2L2PDE4AMAPTALDH1A1 | |
| SCHEMBL9837852 | 0.69 | CYP19A1 (0.44) | NFE2L2NPSR1SLC6A3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | claimed |