Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838394 | 0.89 | BRD4 (0.48) | ALDH1A1POLBBRD4IDO1 | |
| SCHEMBL9836934 | 0.83 | POLB (0.47) | P2RX7KDM4EALDH1A1POLBCYP2A13 | |
| SCHEMBL27571292 | 0.81 | P2RX7 (0.51) | DBHP2RX7KDM4EALDH1A1POLB | |
| SCHEMBL10337098 | 0.76 | TSHR (0.53) | DBHP2RX7ALDH1A1CYP2A13IDO1 | |
| SCHEMBL9836387 | 0.76 | DBH (0.49) | DBHP2RX7ALDH1A1KCNH2BRD4 | |
| SCHEMBL10594477 | 0.75 | MPO (0.44) | KDM4EALDH1A1 | |
| SCHEMBL6348986 | 0.74 | HSD17B10 (0.51) | KDM4EALDH1A1POLBQPCTLBRD4 | |
| SCHEMBL9837718 | 0.73 | CYP11B1 (0.51) | DBHKDM4EALDH1A1BRD4 | |
| SCHEMBL9838297 | 0.73 | MEN1 (0.51) | DBHALDH1A1KCNH2BRD4 | |
| SCHEMBL10593660 | 0.72 | ALDH1A1 (0.50) | DBHP2RX7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125033-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-26 | — | — | EP | claimed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0212066-B1 | INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| EP-0125033-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0308573-A2 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-29 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| EP-0212066-A1 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-03-04 | — | — | EP | disclosed |
| EP-0125033-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |