Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838375 | 0.83 | KDM4E (0.51) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL15451033 | 0.81 | KDM4E (0.51) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL12509441 | 0.76 | FGFR1 (0.53) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL15450928 | 0.74 | LMNA (0.49) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL10813052 | 0.73 | CYP1A2 (0.59) | KDM4EFGFR1FGFR2ALDH1A1HPGD | |
| SCHEMBL16373371 | 0.73 | PARP1 (0.39) | KDM4E | |
| SCHEMBL4062168 | 0.72 | ALDH1A1 (0.60) | KDM4EGAAGDAFGFR1ALDH1A1 | |
| SCHEMBL29123832 | 0.71 | KDM4E (0.68) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL29775257 | 0.70 | KDM4E (0.59) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL15530247 | 0.70 | KDM4E (0.59) | KDM4EGAAGDAFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | disclosed |