Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838320 | 0.83 | KDM4E (0.58) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL15530247 | 0.75 | KDM4E (0.59) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL29775257 | 0.75 | KDM4E (0.59) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL9838795 | 0.74 | CYP1A2 (0.49) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL10514549 | 0.72 | GART (0.57) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL4062168 | 0.69 | ALDH1A1 (0.60) | KDM4EGAAGDAFGFR1ALDH1A1 | |
| SCHEMBL9581457 | 0.68 | GDA (0.89) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL29123832 | 0.68 | KDM4E (0.68) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL15451033 | 0.67 | KDM4E (0.51) | KDM4EGAAGDAFGFR1FGFR2 | |
| SCHEMBL219478 | 0.67 | GDA (1.00) | KDM4EGAAGDAFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305667-A2 | Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | claimed |
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0305667-A2 | Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | disclosed |