Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.60 |
| ▸ | FEN1 | P39748 | 1/20 | 0.60 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301139 | 0.86 | MAPK1 (0.64) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL10437685 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL27182280 | 0.82 | ERCC5 (0.77) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL11453430 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL4833392 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL8534233 | 0.80 | SMN1; SMN2 (0.84) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL10789985 | 0.80 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL13267783 | 0.78 | MAPT (1.00) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL1928026 | 0.78 | MAPT (1.00) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B | |
| SCHEMBL22004470 | 0.78 | GSK3B (1.00) | SMN1; SMN2MAPTL3MBTL1PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028603-A | Platelet-Activating Factor Antagonist; Useful In Treatment Of Inflammatory Diseases, Allergic Diseases, Asthma, Respiratory System Disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0316456-A1 | ESTER-SUBSTITUTED THIENOTRIAZOLODIAZEPINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-24 | — | — | EP | disclosed |
| US-4618617-A | ANTIINFLAMMATORY, ANALGESIC AGENTS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-10-21 | — | — | US | disclosed |