Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749227 | 0.82 | POLB (0.32) | POLBALDH1A1SMN1; SMN2ATMMEN1 | |
| SCHEMBL4157144 | 0.81 | OPRM1 (0.33) | POLBALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL112279 | 0.81 | POLB (0.34) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22234663 | 0.81 | MAPK1 (0.39) | POLBALDH1A1SMN1; SMN2LMNAATM | |
| SCHEMBL21936501 | 0.80 | POLB (0.32) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL26984722 | 0.80 | OPRM1 (0.31) | POLBSMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL10747840 | 0.80 | MGAM (0.31) | POLBSMN1; SMN2MGAMGAASI | |
| SCHEMBL961613 | 0.79 | ABCB11 (0.34) | LMNAMEN1KMT2AMAPT | |
| SCHEMBL10705320 | 0.77 | ABCB11 (0.32) | ALDH1A1LMNAMAPTTRPA1 | |
| SCHEMBL7277882 | 0.76 | KDM4E (0.46) | POLBALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749990-B2 | [3-(2,6-Dimethylbenzyloxy)-phenyl]-oxoacetic acid, useful for the treatment of insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis | WELLSTAT THERAPEUTICS CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-20090005451-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | WELLSTAT THERAPEUTICS CORPORATION (US) | 2009-01-01 | — | — | US | disclosed |
| US-7442796-B2 | Compounds for the treatment of metabolic disorders | WELLSTAT THERAPEUTICS CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070173544-A1 | Compounds for the treatment of metabolic disorders | PHARMA CINQ, LLC | 2007-07-26 | — | — | US | disclosed |
| WO-1991002741-A1 | SUGAR ALCOHOL DERIVATIVES, A PROCESS FOR PREPARING 3-DEOXY-2-OCTULOSONIC ACID AND 3-DEOXY-2-HEPTULOSONIC ACID COMPOUNDS AND DERIVATIVES | RIJKSUNIVERSITEIT TE LEIDEN (NL) | 1991-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173544-A1 | Compounds for the treatment of metabolic disorders | CPT1B, GPR119, CPT1A | POLB 1750/4885ALDH1A1 2897/4885SMN1; SMN2 1064/4885 |
| US-20090005451-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | CPT1B, FABP1, CPT1A | POLB 2115/4885ALDH1A1 2329/4885SMN1; SMN2 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.