Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 7/20 | 0.43 |
| ▸ | HSPA2 | P54652 | 4/20 | 0.43 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353722 | 0.91 | ALDH1A1 (0.49) | ALDH1A1TDP1LMNATSHRHSPA5 | |
| SCHEMBL10665049 | 0.88 | CYP1A2 (0.46) | ALDH1A1TDP1LMNATSHRHSPA5 | |
| SCHEMBL10841495 | 0.87 | ALDH1A1 (0.46) | ALDH1A1TDP1LMNATSHRHSPA5 | |
| SCHEMBL9601530 | 0.87 | ALDH1A1 (0.43) | ALDH1A1TDP1LMNAHTTSMN1; SMN2 | |
| SCHEMBL10353587 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TDP1HTTSMN1; SMN2MEN1 | |
| SCHEMBL9838907 | 0.84 | MAPK1 (0.44) | ALDH1A1LMNAFFAR2MEN1KMT2A | |
| SCHEMBL10665747 | 0.80 | SMN1; SMN2 (0.47) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL10731537 | 0.77 | HTT (0.42) | LMNATSHRHSPA5HSPA2HSPA9 | |
| SCHEMBL10731544 | 0.76 | HSPA5 (0.42) | ALDH1A1TDP1LMNATSHRHSPA5 | |
| SCHEMBL9838921 | 0.73 | MAPK1 (0.46) | ALDH1A1TDP1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |