Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838921 | 0.89 | MAPK1 (0.46) | MAPK1LMNAPOLBGAAALDH1A1 | |
| SCHEMBL9839292 | 0.84 | ALDH1A1 (0.46) | FFAR2LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL10353499 | 0.74 | RAB9A (0.43) | MAPK1POLBALDH1A1HPGDKDM4E | |
| SCHEMBL10353722 | 0.74 | ALDH1A1 (0.49) | MAPK1LMNAPOLBALDH1A1HPGD | |
| Bromide SCHEMBL6152082 | 0.73 | GAA (0.69) | POLBGAAALDH1A1KMT2ANPC1 | |
| SCHEMBL10841495 | 0.71 | ALDH1A1 (0.46) | LMNAPOLBALDH1A1HPGDKMT2A | |
| SCHEMBL9601530 | 0.71 | ALDH1A1 (0.43) | MAPK1LMNAGAAALDH1A1HPGD | |
| SCHEMBL10947190 | 0.70 | ALDH1A1 (0.61) | MAPK1LMNAPOLBGAAALDH1A1 | |
| SCHEMBL10660295 | 0.69 | NPC1 (0.46) | FFAR2LMNAPOLBGAAALDH1A1 | |
| SCHEMBL10353587 | 0.67 | ALDH1A1 (0.51) | MAPK1POLBGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |