Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665049 | 0.89 | CYP1A2 (0.46) | ALDH1A1TDP1LMNAMAPK1MEN1 | |
| SCHEMBL10353722 | 0.88 | ALDH1A1 (0.49) | ALDH1A1TDP1NPC1RAB9ALMNA | |
| SCHEMBL9839292 | 0.87 | ALDH1A1 (0.46) | ALDH1A1TDP1NPC1RAB9ALMNA | |
| SCHEMBL10841495 | 0.85 | ALDH1A1 (0.46) | ALDH1A1TDP1NPC1RAB9ALMNA | |
| SCHEMBL10353587 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TDP1NPC1RAB9AGAA | |
| SCHEMBL10665747 | 0.76 | SMN1; SMN2 (0.47) | ALDH1A1NPC1RAB9ALMNATP53 | |
| SCHEMBL9838921 | 0.75 | MAPK1 (0.46) | ALDH1A1TDP1NPC1RAB9AGAA | |
| SCHEMBL9838907 | 0.71 | MAPK1 (0.44) | ALDH1A1NPC1RAB9AGAALMNA | |
| SCHEMBL9602453 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TDP1NPC1RAB9ALMNA | |
| SCHEMBL10353499 | 0.70 | RAB9A (0.43) | ALDH1A1RAB9AMAPK1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214004-B1 | 4-OH-QUINOLINE-CARBOXYLIC-ACID DERIVATIVES SUBSTITUTED IN POSITION 2 BY A DIHYDROXY-SUBSTITUTED GROUP, POSSIBLY ETHERIFIED OR ESTERIFIED, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-31 | — | — | EP | disclosed |
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |