Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559106 | 0.87 | TSHR (0.45) | KDM4ETDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL9559110 | 0.86 | TDP1 (0.50) | KDM4ETDP1ALOX15CYP2C19MAPT | |
| SCHEMBL7702154 | 0.83 | GAA (0.41) | TDP1ALOX15TSHRCYP2C19HIF1A | |
| SCHEMBL9838242 | 0.82 | TDP1 (0.44) | KDM4ETDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL9837613 | 0.80 | HDAC3 (0.53) | TDP1ALOX15TSHRCYP2C19MAPT | |
| SCHEMBL9558970 | 0.77 | ALDH1A1 (0.39) | KDM4ETDP1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL9558860 | 0.73 | MAPT (0.49) | KDM4EALOX15CYP2C19HIF1AMAPT | |
| SCHEMBL9550724 | 0.72 | THRB (0.41) | TDP1TSHRMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL28264607 | 0.72 | ALOX15 (0.55) | KDM4ETDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL9550717 | 0.72 | THRB (0.40) | TDP1ALOX15TSHRCYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071876-A | Antiinflammatory agent; antiallergen; skin disorders; asthma; enzyme inhibitors of 5-lipogenase | G. D. SEARLE & CO. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0190682-B1 | NOVEL DISUBSTITUTED 4-HYDROXYPHENYLTHIO ANILIDES | G.D. Searle & Co. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0190682-A2 | Novel disubstituted 4-hydroxyphenylthio anilides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |