Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839472 | 0.81 | POLB (0.31) | CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL9742994 | 0.72 | CYP2C19 (0.41) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL20078217 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9742548 | 0.68 | MAPK14 (0.43) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL12991482 | 0.67 | MEN1 (0.58) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9743602 | 0.67 | MAPT (0.58) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| Methylethylamine SCHEMBL11375480 | 0.66 | MAPK14 (0.53) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| Diethylamine SCHEMBL9435597 | 0.66 | MAPK14 (0.53) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9744026 | 0.65 | MAPT (0.58) | MEN1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL18884070 | 0.64 | MEN1 (0.54) | MEN1KMT2AALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |