Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840265 | 0.81 | MEN1 (0.42) | CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL9747245 | 0.73 | POLB (0.40) | POLBLMNACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL9749415 | 0.68 | MAPK14 (0.52) | POLBLMNASMN1; SMN2 | |
| SCHEMBL9840784 | 0.59 | MAPT (0.50) | POLBLMNASMN1; SMN2 | |
| SCHEMBL8036339 | 0.57 | NPC1 (0.37) | LMNASMN1; SMN2 | |
| SCHEMBL18838747 | 0.56 | NPC1 (0.44) | POLBLMNASMN1; SMN2 | |
| SCHEMBL4274617 | 0.55 | TSHR (0.47) | SMN1; SMN2 | |
| SCHEMBL4270831 | 0.55 | TSHR (0.47) | SMN1; SMN2 | |
| SCHEMBL4270037 | 0.55 | TSHR (0.47) | SMN1; SMN2 | |
| SCHEMBL45798 | 0.53 | MGLL (0.39) | LMNACYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0203787-A2 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |