Terephthalamide

Terephthalamide

SCHEMBL9842226

NC(=O)c1ccc(C(N)=O)cc1.NCc1cccc(CN)c1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G10 O15496 1/20 0.57
PLA2G2A P14555 1/20 0.57
LOXL2 Q9Y4K0 3/20 0.55
ENPP2 Q13822 1/20 0.52
NOS1 P29475 3/20 0.50
NOS2 P35228 3/20 0.50
ALDH1A1 P00352 2/20 0.50
NOS3 P29474 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
CYP3A4 P08684 2/20 0.50
NFKB1 P19838 1/20 0.50
PARP10 Q53GL7 3/20 0.49
MAOB P27338 1/20 0.49
PLAU P00749 1/20 0.49
PARP15 Q460N3 1/20 0.49
PARP14 Q460N5 1/20 0.49
POLB P06746 1/20 0.48
PARP1 P09874 1/20 0.48
MAPT P10636 1/20 0.48
TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9842445 0.90 LOXL2 (0.58) PLA2G10PLA2G2ALOXL2ENPP2NOS1
SCHEMBL29364575 0.88 LOXL2 (0.66) PLA2G10PLA2G2ALOXL2ENPP2NOS1
SCHEMBL509423 0.88 LOXL2 (0.66) PLA2G10PLA2G2ALOXL2ENPP2NOS1
SCHEMBL3722171 0.87 AOC3 (0.63) PLA2G10PLA2G2ALOXL2AOC3
Terephthalamide SCHEMBL3444098 0.87 LOXL2 (0.60) PLA2G10PLA2G2ALOXL2ALDH1A1CYP3A4
SCHEMBL509167 0.87 LOXL2 (0.60) PLA2G10PLA2G2ALOXL2ALDH1A1CYP3A4
Benzamide SCHEMBL27536269 0.85 PARP1 (0.70) PLA2G10PLA2G2ALOXL2CYP3A4PARP10
Hydrochloric Acid SCHEMBL31474725 0.85 LOXL2 (0.58) PLA2G10PLA2G2ALOXL2NOS1NOS2
Hydrochloric Acid SCHEMBL3948480 0.85 LOXL2 (0.58) PLA2G10PLA2G2ALOXL2NOS1NOS2
Terephthalic Acid SCHEMBL9858389 0.83 LOXL2 (0.56) LOXL2ENPP2TSHRCYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0411790-A1 Process for the preparation of nylon salts BP Chemicals Limited (GB) 1991-02-06 EP disclosed