SCHEMBL9842445

SCHEMBL9842445

NC(=O)c1cccc(C(N)=O)c1.NCc1cccc(CN)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.58
PARP1 P09874 7/20 0.53
ENPP2 Q13822 1/20 0.50
NOS1 P29475 3/20 0.49
NOS2 P35228 3/20 0.49
ALDH1A1 P00352 2/20 0.49
NOS3 P29474 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
CYP3A4 P08684 2/20 0.49
NFKB1 P19838 1/20 0.49
MEP1B Q16820 1/20 0.47
PLAU P00749 1/20 0.47
TSHR P16473 2/20 0.46
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C19 P33261 1/20 0.46
RECQL P46063 1/20 0.46
BLM P54132 1/20 0.46
PMP22 Q01453 1/20 0.46
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL509423 0.94 LOXL2 (0.66) LOXL2PARP1ENPP2NOS1NOS2
SCHEMBL29364575 0.94 LOXL2 (0.66) LOXL2PARP1ENPP2NOS1NOS2
Terephthalamide SCHEMBL9842226 0.90 PLA2G10 (0.57) LOXL2PARP1ENPP2NOS1NOS2
SCHEMBL172996 0.87 CFD (0.61) LOXL2PARP1CFD
SCHEMBL10458793 0.85 PARP1 (0.64) PARP1CYP3A4MEP1BTSHRPOLB
Isophthalic Acid SCHEMBL9858510 0.84 FOLH1 (0.58) LOXL2ENPP2PLAUCFD
Benzamide SCHEMBL27536269 0.83 PARP1 (0.70) LOXL2PARP1CYP3A4TSHRPOLB
Ethylenediamine SCHEMBL6068910 0.83 PARP1 (0.61) PARP1CYP3A4MEP1BTSHRPOLB
SCHEMBL31021028 0.82 PARP1 (0.73) PARP1CYP3A4TSHRPOLBMAPT
SCHEMBL36694 0.82 PARP1 (0.73) PARP1CYP3A4TSHRPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1902838-B1 MULTI-LAYERED BOTTLE MITSUBISHI GAS CHEMICAL CO (JP) 2016-11-09 EP disclosed
EP-2505354-B1 Multi-layered bottle MITSUBISHI GAS CHEMICAL CO (JP) 2016-10-19 EP disclosed
EP-0411790-A1 Process for the preparation of nylon salts BP Chemicals Limited (GB) 1991-02-06 EP disclosed