Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 4/20 | 0.63 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | CFD | P00746 | 2/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172996 | 0.88 | CFD (0.61) | AOC3CFDLOXL2 | |
| Terephthalamide SCHEMBL9842226 | 0.87 | PLA2G10 (0.57) | AOC3PLA2G10PLA2G2ALOXL2 | |
| SCHEMBL1789918 | 0.87 | AOC3 (0.60) | AOC3BCL2MKNK1MKNK2ABHD6 | |
| SCHEMBL14496864 | 0.86 | BCL2 (0.71) | AOC3BCL2CFDHDAC1TAAR1 | |
| SCHEMBL15634050 | 0.85 | AOC3 (0.58) | AOC3BCL2MKNK1MKNK2ABHD6 | |
| Hydrochloric Acid SCHEMBL5548244 | 0.85 | BCL2 (0.69) | AOC3BCL2CFDHDAC1TAAR1 | |
| SCHEMBL3717108 | 0.85 | MAPT (0.56) | AOC3BCL2CFDHDAC1TAAR1 | |
| SCHEMBL27352380 | 0.84 | ERN1 (0.54) | AOC3CFDHDAC1TAAR1 | |
| SCHEMBL3794460 | 0.81 | TAAR1 (0.70) | CFDTAAR1LOXL2 | |
| SCHEMBL22367342 | 0.81 | MKNK1 (0.64) | AOC3MKNK1MKNK2PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| CN-107652200-B | A method of N- aryl Zhong Fang amide is synthesized using aryl hydrazine | 陕西科技大学 | 2019-06-14 | — | — | CN | disclosed |
| CN-107652200-A | A kind of method that N aryl Zhong Fang acid amides is synthesized using aryl hydrazine | 陕西科技大学 | 2018-02-02 | — | — | CN | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |