Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340718 | 0.82 | CA2 (0.53) | ALDH1A1CYP2C9TYRPOLBSMN1; SMN2 | |
| SCHEMBL18648678 | 0.81 | POLB (0.51) | ALDH1A1ALOX15LMNAHSD17B10HTT | |
| SCHEMBL28481719 | 0.79 | ESR2 (0.46) | ALDH1A1ESR2ESR1KDM4EMAPT | |
| SCHEMBL6512405 | 0.76 | ESR2 (0.46) | ALDH1A1ALOX15LMNAHSD17B10ESR2 | |
| SCHEMBL6516626 | 0.76 | ESR2 (0.44) | ALDH1A1LMNAHSD17B10ESR2ESR1 | |
| SCHEMBL1176397 | 0.75 | ALDH1A1 (0.67) | ALDH1A1ALOX15LMNAHSD17B10HTT | |
| SCHEMBL31146788 | 0.75 | ALDH1A1 (0.67) | ALDH1A1ALOX15LMNAHSD17B10HTT | |
| SCHEMBL11124529 | 0.73 | ALDH1A1 (0.46) | ALDH1A1ALOX15LMNAHSD17B10HTT | |
| SCHEMBL13104330 | 0.73 | KIF11 (0.48) | ALDH1A1LMNAHTTKDM4EMAPT | |
| SCHEMBL23869711 | 0.72 | ERN1 (0.53) | ALDH1A1ALOX15LMNAHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432740-A2 | 2-Substituted 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, process for their preparation, medicaments containing them and their utilization | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-19 | — | — | EP | claimed |