Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843014 | 0.85 | NPC1 (0.60) | HDAC3HDAC8HDAC6TRPV1NPC1 | |
| SCHEMBL9842954 | 0.81 | NQO2 (0.54) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL11435148 | 0.81 | TRPV1 (0.56) | HDAC3HDAC8HDAC6TRPV1NPC1 | |
| SCHEMBL7303163 | 0.81 | HDAC3 (0.86) | HDAC3HDAC11HDAC8HDAC6TRPV1 | |
| SCHEMBL8597230 | 0.80 | NPC1 (0.56) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9081513 | 0.80 | TRPV1 (0.50) | TRPV1NPC1RAB9ANAMPTMEN1 | |
| SCHEMBL8808773 | 0.80 | MAPK1 (0.57) | NPC1RAB9ASMN1; SMN2NAMPTKDR | |
| SCHEMBL8811207 | 0.80 | TP53 (0.54) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL892704 | 0.80 | HTT (0.54) | HDAC8HDAC6NPC1RAB9ANAMPT | |
| SCHEMBL9843089 | 0.79 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | claimed |