Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.57 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | CCKBR | P32239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11435148 | 0.95 | TRPV1 (0.56) | NPC1RAB9ATRPV1PTGS1RORC | |
| SCHEMBL11427050 | 0.92 | TRPV1 (0.56) | NPC1RAB9ATRPV1PTGS1RORC | |
| SCHEMBL9842872 | 0.85 | HDAC3 (0.59) | NPC1RAB9ATRPV1SMN1; SMN2CYP1A2 | |
| SCHEMBL8597230 | 0.83 | NPC1 (0.56) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL9842888 | 0.82 | TRPV1 (0.60) | NPC1RAB9ATRPV1SMN1; SMN2LMNA | |
| SCHEMBL9842954 | 0.81 | NQO2 (0.54) | NPC1RAB9ALMNATP53CYP3A4 | |
| SCHEMBL6709253 | 0.81 | KIF11 (0.50) | TRPV1NPSR1TRPV4 | |
| SCHEMBL7513604 | 0.81 | TRPV1 (0.83) | NPC1RAB9ATRPV1PTGS1RORC | |
| SCHEMBL8811207 | 0.80 | TP53 (0.54) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL9081513 | 0.80 | TRPV1 (0.50) | NPC1RAB9ATRPV1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | claimed |
| EP-3310755-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | Biocon Limited (IN) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016203410-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | BIOCON LIMITED (IN) | 2016-12-22 | — | — | WO | disclosed |
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |