Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27887659 | 0.84 | GRIN2B (0.56) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18690747 | 0.76 | MALT1 (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL18690746 | 0.76 | MALT1 (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL11304571 | 0.75 | GRIN1 (0.43) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9843255 | 0.73 | POLB (0.41) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11114919 | 0.71 | GRIN2B (0.50) | POLBGRIN1GRIN2B | |
| SCHEMBL9017815 | 0.69 | ALDH1A1 (0.47) | SMN1; SMN2 | |
| SCHEMBL9017817 | 0.69 | ALDH1A1 (0.47) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7676588 | 0.67 | NOS2 (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL9547058 | 0.67 | NOS2 (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1050186-A | Guanidine derivative | CIBA GEIGY AG (CH) | 1991-03-27 | — | — | CN | claimed |
| EP-0418199-A2 | Guanidine derivatives | CIBA-GEIGY AG (CH) | 1991-03-20 | — | — | EP | claimed |
| CN-1050186-A | Guanidine derivative | CIBA GEIGY AG (CH) | 1991-03-27 | — | — | CN | disclosed |
| EP-0418199-A2 | Guanidine derivatives | CIBA-GEIGY AG (CH) | 1991-03-20 | — | — | EP | disclosed |