SCHEMBL9843176

SCHEMBL9843176

O=C(O)[C@H](Cc1ccccc1)Nc1ccc(Cl)cc1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 1/20 0.57
MMP2 P08253 1/20 0.57
PPARG P37231 6/20 0.55
FPR2 P25090 7/20 0.55
PPARA Q07869 3/20 0.51
MME P08473 1/20 0.49
GPR34 Q9UPC5 1/20 0.48
PYGL P06737 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1533645 0.88 PPARG (0.58) MMP2PPARGFPR2MMENPSR1
SCHEMBL1533647 0.88 PPARG (0.58) MMP2PPARGFPR2MMENPSR1
SCHEMBL6250861 0.88 PPARG (0.58) MMP2PPARGFPR2MMENPSR1
SCHEMBL71614 0.87 MME (0.59) ADAMTS5MMP2PPARGFPR2MME
SCHEMBL28789648 0.85 PPARG (0.60) PPARGFPR2MMENPSR1
SCHEMBL29166010 0.85 PPARG (0.56) MMP2PPARGFPR2MMENPSR1
SCHEMBL28789647 0.85 PPARG (0.60) PPARGFPR2MMENPSR1
SCHEMBL27509445 0.84 ALDH1A1 (0.59) PPARGFPR2PPARAMMEGPR34
SCHEMBL27746696 0.84 ALDH1A1 (0.59) PPARGFPR2PPARAMMEGPR34
SCHEMBL7100965 0.84 PPARG (0.55) PPARGFPR2MMENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0428019-A1 Polyethersulfone-polyarylenesulfide block copolymers and process for making them BAYER AG (DE) 1991-05-22 EP disclosed
EP-0381867-A2 Polyether ether ketone-polyarylene sulfide block copolymers BAYER AG (DE) 1990-08-16 EP disclosed