Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843662 | 0.81 | MAPT (0.37) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL9843881 | 0.81 | MAPT (0.37) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL12712130 | 0.79 | ADORA2A (0.31) | — | |
| SCHEMBL9843764 | 0.78 | GCGR (0.33) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL9738686 | 0.76 | PDE4A (0.33) | TLR8TLR7SIRT1NOS2 | |
| SCHEMBL9738954 | 0.76 | ADORA2A (0.40) | TLR8TLR7CASP1SIRT1NOS2 | |
| SCHEMBL10922045 | 0.76 | — | — | |
| SCHEMBL2229077 | 0.75 | LMNA (0.45) | HPGDHTTMAPTLMNA | |
| SCHEMBL27477358 | 0.74 | MAPT (0.38) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL28868241 | 0.73 | LMNA (0.42) | NPC1HPGDMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407342-A2 | Pyrimidine derivatives | CIBA-GEIGY AG (CH) | 1991-01-09 | — | — | EP | disclosed |