Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843662 | 0.89 | MAPT (0.37) | MAPTLMNAHTTNPSR1NPC1 | |
| SCHEMBL27477358 | 0.87 | MAPT (0.38) | MAPTLMNAHTTNPSR1NPC1 | |
| SCHEMBL28619888 | 0.84 | POLB (0.45) | LMNAHTTNPSR1HPGDPOLB | |
| SCHEMBL2229077 | 0.83 | LMNA (0.45) | MAPTLMNAHTTHPGDPOLB | |
| SCHEMBL2227651 | 0.81 | LMNA (0.39) | MAPTLMNAHTTTLR8TLR7 | |
| SCHEMBL9843680 | 0.81 | NPC1 (0.34) | MAPTLMNAHTTNPSR1NPC1 | |
| SCHEMBL28628793 | 0.78 | TSHR (0.53) | LMNATLR7KDM4ETSHR | |
| SCHEMBL29703417 | 0.78 | TSHR (0.53) | LMNATLR7KDM4ETSHR | |
| SCHEMBL6414929 | 0.76 | TLR8 (0.56) | TLR8TLR7 | |
| Ethirimol SCHEMBL20692 | 0.75 | TLR8 (0.41) | MAPTLMNAHTTNPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407342-A2 | Pyrimidine derivatives | CIBA-GEIGY AG (CH) | 1991-01-09 | — | — | EP | disclosed |