Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759502 | 0.81 | HPGD (0.57) | HPGDRECQLPKMSMN1; SMN2NPC1 | |
| SCHEMBL4458878 | 0.73 | PKM (0.58) | PKMSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL1848757 | 0.73 | PKM (0.50) | PKMSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL323668 | 0.71 | ALDH1A1 (0.50) | PKMSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6449861 | 0.71 | CYP3A4 (0.58) | PKMSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL18230248 | 0.71 | CES2 (0.53) | HPGDRECQLSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL38661039 | 0.71 | CES2 (0.58) | PKMSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL11715964 | 0.69 | EPHX2 (0.41) | HPGDNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5042317 | 0.68 | CYP3A4 (0.58) | PKMSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL31098460 | 0.68 | SMN1; SMN2 (0.47) | HPGDRECQLPKMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417721-A2 | Novel peptidase and isomerase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-20 | — | — | EP | claimed |