Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.61 |
| ▸ | GART | P22102 | 9/20 | 0.55 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.55 |
| ▸ | FOLR1 | P15328 | 3/20 | 0.55 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.55 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.55 |
| ▸ | ATIC | P31939 | 2/20 | 0.53 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844801 | 0.95 | DHFR (0.60) | DHFRGARTTYMS | |
| SCHEMBL10405409 | 0.84 | DHFR (0.63) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9844791 | 0.82 | GART (0.73) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9844911 | 0.82 | DHFR (0.56) | DHFRTYMS | |
| SCHEMBL9263780 | 0.81 | GART (0.67) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9339136 | 0.81 | GART (0.68) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9339203 | 0.81 | DHFR (0.69) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9844840 | 0.80 | DHFR (0.56) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9225374 | 0.80 | DHFR (0.80) | DHFRGARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL9223840 | 0.79 | GART (0.72) | DHFRGARTFOLR2FOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |