SCHEMBL9844869

SCHEMBL9844869

CC(=O)Oc1c(C)cc(S(=O)(=O)Cl)c(C)c1C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.41
KDM4E B2RXH2 2/20 0.41
HSD17B10 Q99714 2/20 0.41
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
GAA P10253 1/20 0.41
POLB P06746 3/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.34
ABCB11 O95342 1/20 0.33
ELANE P08246 1/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 3/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ACHE P22303 3/20 0.32
BACE1 P56817 1/20 0.32
CYP3A4 P08684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1038076 0.79 ALDH1A1 (0.57) HTTMAPTTP53POLBALDH1A1
SCHEMBL9844867 0.76 MCL1 (0.41) HTTKDM4EHSD17B10GAAPOLB
SCHEMBL10941837 0.76 KDM4E (0.49) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL10624847 0.76 KDM4E (0.52) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL2910532 0.74 POLB (0.62) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL9596191 0.74 HTT (0.47) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL721909 0.73 HTT (0.59) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL7526380 0.72 TRPV4 (0.34) ALDH1A1
SCHEMBL3609168 0.72 HTT (0.45) HTTKDM4EHSD17B10MAPTTP53
SCHEMBL13954030 0.72 POLB (0.54) HTTKDM4EHSD17B10MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0413839-A1 GHRH analogs The Administrators of The Tulane Educational Fund (US) 1991-02-27 EP disclosed
US-4914189-A STIMULATES RELEASE OF GROWTH HORMONE THE ADMINSTRATORS OF THE TULANE EDUCATIONAL FUND (US) 1990-04-03 US disclosed