Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7201805 | 0.81 | IGF1R (0.42) | MAOAMEN1KMT2AAURKADAPK3 | |
| SCHEMBL9844863 | 0.75 | SRD5A1 (0.47) | GAAMAOAMEN1KMT2AL3MBTL1 | |
| SCHEMBL631900 | 0.74 | MGAM (0.75) | MGAMGAASIMGAM2ESR2 | |
| SCHEMBL10431895 | 0.73 | SRD5A1 (0.43) | MGAMGAASIMGAM2MAOA | |
| SCHEMBL9816460 | 0.71 | NQO2 (0.50) | ESR2MEN1KMT2AESR1 | |
| SCHEMBL3881299 | 0.71 | GAA (0.57) | MGAMGAASIMGAM2ESR2 | |
| SCHEMBL11591196 | 0.71 | GAA (0.56) | MGAMGAASIMGAM2ESR2 | |
| SCHEMBL27656194 | 0.71 | AURKA (0.42) | MAOAMEN1KMT2AAURKADAPK3 | |
| SCHEMBL28194247 | 0.70 | MAOA (0.53) | MGAMGAASIMGAM2MAOA | |
| SCHEMBL3799324 | 0.69 | CA12 (0.57) | MAOAMEN1KMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420571-A2 | 6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |