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Naptalam

Naptalam

SCHEMBL984498

O=C(O)c1ccccc1C(=O)Nc1cccc2ccccc12.[NaH]

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 1/20 0.72
▸ CHRNB2 P17787 1/20 0.68
▸ CHRNB4 P30926 1/20 0.68
▸ CHRNA3 P32297 1/20 0.68
▸ CHRNA4 P43681 1/20 0.68
▸ NPC1 O15118 3/20 0.68
▸ RAB9A P51151 3/20 0.68
▸ CYP1A2 P05177 1/20 0.66
▸ CYP3A4 P08684 1/20 0.66
▸ CYP2D6 P10635 1/20 0.66
▸ CYP2C9 P11712 1/20 0.66
▸ CYP2C19 P33261 1/20 0.66
▸ GFER P55789 1/20 0.61
▸ KMT2A Q03164 3/20 0.58
▸ GAA P10253 2/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ TP53 P04637 1/20 0.58
▸ NFKB1 P19838 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naptalam SCHEMBL8537412 0.98 HSD17B10 (0.74) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
Naptalam SCHEMBL29610802 0.98 HSD17B10 (0.74) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
Naptalam SCHEMBL29469565 0.98 HSD17B10 (0.74) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
Naptalam SCHEMBL54940 0.98 HSD17B10 (0.74) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL13927141 0.90 HSD17B10 (0.61) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL21275460 0.86 RAB9A (0.76) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL9281809 0.85 GFER (0.76) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
Naptalam SCHEMBL8382453 0.85 HSD17B10 (0.58) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL4926868 0.84 KDM4E (0.72) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL12172779 0.84 GFER (0.69) HSD17B10CHRNB2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506014-A4 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2006-09-20 — — EP claimed
US-20050238693-A1 Process for the preparation and activation of susbstances and a means of producing same CHEMSTOP PTY LTD. (AU) 2005-10-27 — — US claimed
EP-1506014-A1 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2005-02-16 — — EP claimed
WO-2003097095-A1 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2003-11-27 — — WO claimed
EP-2346321-B2 COMPOSITION FOR IMPROVING THE EFFICACY OF HERBICIDES BASF SE (DE) 2022-05-18 — — EP disclosed
CN-111801012-A Plants with increased herbicide tolerance 巴斯夫欧洲公司 2020-10-20 — — CN disclosed
CN-111601893-A Plants with increased herbicide tolerance 巴斯夫欧洲公司 2020-08-28 — — CN disclosed
CN-106460007-B Plants with increased herbicide tolerance 巴斯夫欧洲公司 2020-07-31 — — CN disclosed
CN-104684392-B Include the Herbicidal combinations of the carboxylic acid of 4 amino, 3 chlorine 5 fluorine 6 (methoxyphenyl of 4 chlorine, 2 fluorine 3) pyridine 2 美国陶氏益农公司 2017-08-29 — — CN disclosed
US-9253984-B2 Herbicidal compositions comprising pyroxasulfone VII BASF SE (DE) 2016-02-09 — — US disclosed
WO-2015097071-A1 HERBICIDAL HALOALKYLSULPHONAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2015-07-02 — — WO disclosed
CN-101983011-B Herbicidal compositions comprising pyroxasulfone vii BASF SE 2014-05-07 — — CN disclosed
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2006-12-07 — — US disclosed
EP-1506014-A4 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2006-09-20 — — EP disclosed
US-20050279019-A1 Cover layers to prevent weed growth NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2005-12-22 — — US disclosed
US-20050238693-A1 Process for the preparation and activation of susbstances and a means of producing same CHEMSTOP PTY LTD. (AU) 2005-10-27 — — US disclosed
EP-1562415-A1 COVER LAYERS TO PREVENT WEED GROWTH NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2005-08-17 — — EP disclosed
EP-1506014-A1 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2005-02-16 — — EP disclosed
WO-2004047520-A1 COVER LAYERS TO PREVENT WEED GROWTH NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2004-06-10 — — WO disclosed
WO-2003097095-A1 PROCESS FOR THE PREPARATION AND ACTIVATION OF SUBSTANCES AND A MEANS OF PRODUCING SAME CHEMSTOP PTY LTD (AU) 2003-11-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients ENPP1, ENPP3, SMPD1 HSD17B10 2715/4885CHRNB2 4342/4885CHRNB4 4267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.