Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208190 | 0.97 | MAPT (0.38) | MAPTGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL984966 | 0.83 | MAPT (0.41) | MAPTGAASMN1; SMN2KDM4EALDH1A1 | |
| Lithium Ion SCHEMBL30093254 | 0.77 | THRB (0.30) | — | |
| SCHEMBL8321058 | 0.74 | THRB (0.30) | — | |
| SCHEMBL1155361 | 0.74 | THRB (0.30) | — | |
| SCHEMBL9217708 | 0.74 | THRB (0.30) | — | |
| SCHEMBL9268300 | 0.72 | ALDH1A1 (0.48) | MAPTSMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL1155647 | 0.72 | — | — | |
| SCHEMBL1285713 | 0.72 | MAPT (0.46) | MAPTGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2255782 | 0.71 | MAPT (0.50) | MAPTGAASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2232611-A1 | BARRIER COATED SUBSTRATE AND ELECTRO-OPTICAL DEVICE | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009090423-A1 | BARRIER COATED SUBSTRATE AND ELECTRO-OPTICAL DEVICE | MERCK PATENT GMBH (DE) | 2009-07-23 | — | — | WO | claimed |
| US-20070200096-A1 | Doped lithium quinolate | OLED-T LIMITED (GB) | 2007-08-30 | — | — | US | claimed |
| US-9221770-B2 | Compounds having electron transport properties, their preparation and use | MERCK PATENT GMBH (DE) | 2015-12-29 | — | — | US | disclosed |
| EP-2318474-B1 | COMPOUND HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES AND ITS PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2015-05-27 | — | — | EP | disclosed |
| US-8507896-B2 | Compounds having electroluminescent or electron transport properties | MERCK PATENT GMBH (DE) | 2013-08-13 | — | — | US | disclosed |
| US-20110108819-A1 | COMPOUNDS HAVING ELECTRON TRANSPORT PROPERTIES, THEIR PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2011-05-12 | — | — | US | disclosed |
| EP-2318474-A1 | COMPOUND HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES AND ITS PREPARATION AND USE | Merck Patent GmbH (DE) | 2011-05-11 | — | — | EP | disclosed |
| EP-2313383-A1 | COMPOUNDS HAVING ELECTRON TRANSPORT PROPERTIES, THEIR PREPARATION AND USE | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |
| US-20110006295-A1 | COMPOUNDS HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES | MERCK PATENT GMBH | 2011-01-13 | — | — | US | disclosed |
| EP-2250151-A1 | COMPOUNDS HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES | Merck Patent GmbH (DE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2010020352-A1 | COMPOUNDS HAVING ELECTRON TRANSPORT PROPERTIES, THEIR PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010017896-A1 | COMPOUND HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES AND ITS PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2010-02-18 | — | — | WO | disclosed |
| WO-2009112854-A1 | COMPOUNDS HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES | MERCK PATENT GMBH (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110006295-A1 | COMPOUNDS HAVING ELECTROLUMINESCENT OR ELECTRON TRANSPORT PROPERTIES | NR2E3, NR4A2, NR4A3 | MAPT 3534/4885GAA 4048/4885SMN1; SMN2 1611/4885 |
| US-20110108819-A1 | COMPOUNDS HAVING ELECTRON TRANSPORT PROPERTIES, THEIR PREPARATION AND USE | SLC25A21, SLCO4C1, SLCO1B3 | MAPT 530/4885GAA 2245/4885SMN1; SMN2 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.