Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 20/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12017334 | 0.81 | OPRD1 (0.43) | OPRD1KCNH2OPRK1 | |
| SCHEMBL9845357 | 0.80 | OPRD1 (0.45) | OPRD1KCNH2OPRK1CYP2D6 | |
| SCHEMBL14666700 | 0.78 | — | — | |
| SCHEMBL14666734 | 0.78 | MAOB (0.41) | CYP2D6 | |
| SCHEMBL9577755 | 0.73 | OPRD1 (0.59) | OPRD1KCNH2OPRK1CYP2D6 | |
| SCHEMBL16315417 | 0.71 | OPRD1 (0.36) | OPRD1KCNH2OPRK1CYP2D6 | |
| SCHEMBL1237576 | 0.70 | OPRD1 (0.80) | OPRD1KCNH2OPRK1CYP2D6 | |
| Lithium Ion SCHEMBL7399401 | 0.70 | OPRD1 (0.54) | OPRD1KCNH2OPRK1CYP2D6 | |
| SCHEMBL10654175 | 0.69 | BACE1 (0.32) | KCNH2 | |
| SCHEMBL10651735 | 0.69 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420266-A2 | Chromene or thiochromene derivatives, process for preparing the same, intermediate therefor, pharmaceutical compositions containing said derivatives and the use of said derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |