Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592274 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDNPSR1GAA | |
| SCHEMBL620266 | 0.70 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDGAAHTT | |
| SCHEMBL12695178 | 0.69 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDGAAHTT | |
| SCHEMBL12836259 | 0.68 | SIGMAR1 (0.43) | ALDH1A1KDM4EHPGDGAAHTT | |
| SCHEMBL12481820 | 0.67 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDNPSR1GAA | |
| SCHEMBL9140221 | 0.67 | MAPT (0.42) | ALDH1A1KDM4EHPGDNPSR1GAA | |
| Hydrochloric Acid SCHEMBL3492537 | 0.66 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGDNPSR1GAA | |
| SCHEMBL13209538 | 0.66 | NPSR1 (0.41) | ALDH1A1KDM4ENPSR1GAAHTT | |
| SCHEMBL9963318 | 0.65 | CYP2D6 (0.42) | ALDH1A1KDM4EHPGDGAAHTT | |
| SCHEMBL9531911 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420266-A2 | Chromene or thiochromene derivatives, process for preparing the same, intermediate therefor, pharmaceutical compositions containing said derivatives and the use of said derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |