SCHEMBL6592274

SCHEMBL6592274

CC1(C)CC(=O)c2ccccc2S1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.46
HPGD P15428 4/20 0.46
ALOX12 P18054 1/20 0.46
KDM4E B2RXH2 5/20 0.44
LMNA P02545 2/20 0.44
HSD17B10 Q99714 2/20 0.44
POLB P06746 2/20 0.44
GAA P10253 2/20 0.44
HTT P42858 2/20 0.44
MAPT P10636 2/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
NPSR1 Q6W5P4 1/20 0.37
ATM Q13315 2/20 0.35
BLM P54132 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
BRD4 O60885 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8606021 0.79 ALDH1A1 (0.37) ALDH1A1HPGDALOX12KDM4ELMNA
SCHEMBL68563 0.77 KDM4E (0.48) ALDH1A1HPGDKDM4ELMNAGAA
SCHEMBL9845356 0.77 ALDH1A1 (0.39) ALDH1A1HPGDKDM4ELMNAHSD17B10
SCHEMBL9379290 0.75 PGR (0.42) ALDH1A1HPGDKDM4EGAAHTT
SCHEMBL68066 0.75 VHL (0.50) ALDH1A1HPGDKDM4EGAAMAPT
SCHEMBL4420836 0.75 S100A4 (0.37) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL85934 0.75 MAPT (0.50) ALDH1A1KDM4ELMNAMAPTKMT2A
SCHEMBL12471284 0.75 MEN1 (0.47) ALDH1A1HPGDALOX12KDM4ELMNA
SCHEMBL4255191 0.75 TDP2 (0.36) ALDH1A1HPGDALOX12KDM4ELMNA
SCHEMBL21497496 0.74 ALDH1A1 (0.49) ALDH1A1HPGDALOX12KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042313-B1 BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST LIKE ACTIVITY ALLERGAN INC (US) 2004-04-28 EP disclosed
US-6599908-B1 Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn CELLTECH R & D LIMITED (GB) 2003-07-29 US disclosed
EP-1042313-A1 BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST LIKE ACTIVITY Allergan Sales, Inc. (US) 2000-10-11 EP disclosed
EP-1031572-A1 PYRIDYLPYRROLE DERIVATIVES Sankyo Company Limited (JP) 2000-08-30 EP disclosed
US-6057329-A Fused polycyclic 2-aminopyrimidine derivatives CELLTECH THERAPEUTICS LIMITED (GB) 2000-05-02 US disclosed
EP-0946523-A1 FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 1999-10-06 EP disclosed
US-5958954-A 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES ALLERGAN SALES, INC. (US) 1999-09-28 US disclosed
WO-1999033821-A1 BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST-LIKE ACTIVITY ALLERGAN SALES, INC. (US) 1999-07-08 WO disclosed
WO-1998028281-A1 FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 1998-07-02 WO disclosed