Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20475293 | 0.89 | ALDH1A1 (0.58) | HPGDTSHRALDH1A1PDE4APDE4B | |
| SCHEMBL16033027 | 0.86 | HPGD (1.00) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL24725852 | 0.86 | ALDH1A1 (0.55) | HPGDTSHRALDH1A1LMNAPDE4A | |
| SCHEMBL24725922 | 0.85 | ALDH1A1 (0.57) | HPGDTSHRALDH1A1PDE4APDE4B | |
| SCHEMBL28658600 | 0.85 | HPGD (0.81) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL20475314 | 0.84 | ALDH1A1 (0.56) | HPGDTSHRALDH1A1PDE4APDE4B | |
| SCHEMBL24725921 | 0.83 | ALDH1A1 (0.55) | HPGDTSHRALDH1A1PDE4APDE4B | |
| SCHEMBL26791211 | 0.80 | ALDH1A1 (0.66) | HPGDTSHRALDH1A1LMNAMAPT | |
| SCHEMBL29936877 | 0.79 | ALDH1A1 (1.00) | HPGDALDH1A1MAPT | |
| SCHEMBL12741617 | 0.79 | ALDH1A1 (1.00) | HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439766-A2 | Process for the preparation of N-acyl-4-phenyl-pyrrolidin-2-ones having cerebroprotective activity | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-08-07 | — | — | EP | disclosed |