SCHEMBL984579

SCHEMBL984579

CN[C@H]1CN(c2ccc3c(=O)c(OC(=O)O)cn(-c4nccs4)c3n2)C[C@@H]1OC

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
PPARG P37231 1/20 0.35
MAPK10 P53779 1/20 0.35
KMT2A Q03164 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
CHRNA7 P36544 3/20 0.32
HTR3A P46098 2/20 0.32
KDM4C Q9H3R0 1/20 0.32
TYK2 P29597 1/20 0.30
HPGDS O60760 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7836101 1.00 ALDH1A1 (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL674441 0.90 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL195037 0.90 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL15933161 0.90 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL3207291 0.90 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL7824869 0.89 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL7824853 0.89 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL7824841 0.89 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL18694851 0.89 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1
Vosaroxin SCHEMBL29914037 0.89 HTR3A (0.35) ALDH1A1PPARGMAPK10KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931339-B1 METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER SUNESIS PHARMACEUTICALS INC (US) 2018-05-16 EP claimed
EP-2214662-B1 (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION WITH GEMCITABINE FOR USE IN TREATING CANCER SUNESIS PHARMACEUTICALS INC (US) 2016-07-13 EP claimed
EP-2049109-B1 COMBINED USE OF (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID AND CYTARABINE (ARA-C) FOR THE TREATMENT OF LEUKEMIA SUNESIS PHARMACEUTICALS INC (US) 2015-11-18 EP claimed
EP-1725233-B1 PHARMACEUTICAL COMPOSITION COMPRISING SNS-595 AND USES THEREOF SUNESIS PHARMACEUTICALS INC (US) 2011-01-05 EP claimed
EP-1931339-B1 METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER SUNESIS PHARMACEUTICALS INC (US) 2018-05-16 EP disclosed
EP-3284745-A1 COMPOSITION OF (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID Sunesis Pharmaceuticals, Inc. (US) 2018-02-21 EP disclosed
EP-2382214-B1 METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID SUNESIS PHARMACEUTICALS INC (US) 2017-07-19 EP disclosed
EP-3141250-A1 METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY Sunesis Pharmaceuticals, Inc. (US) 2017-03-15 EP disclosed
EP-2214662-B1 (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION WITH GEMCITABINE FOR USE IN TREATING CANCER SUNESIS PHARMACEUTICALS INC (US) 2016-07-13 EP disclosed
EP-2049109-B1 COMBINED USE OF (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID AND CYTARABINE (ARA-C) FOR THE TREATMENT OF LEUKEMIA SUNESIS PHARMACEUTICALS INC (US) 2015-11-18 EP disclosed
EP-2249831-A2 METHODS OF USING (+)-1,4-DIHYDRO-7-Ý(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL¨-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF ANTECEDENT HEMATOLOGIC DISORDERS Sunesis Pharmaceuticals, Inc. (US) 2010-11-17 EP disclosed
EP-2214662-A1 METHODS OF USING (+)-1,4-DIHYDRO-7-Ý(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL¨-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY Sunesis Pharmaceuticals, Inc. (US) 2010-08-11 EP disclosed
EP-2049109-A2 COMBINED USE OF (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID AND CYTARABINE (ARA-C) FOR THE TREATMENT OF LEUKEMIA Sunesis Pharmaceuticals, Inc. (US) 2009-04-22 EP disclosed
EP-1931339-A1 METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER Sunesis Pharmaceuticals, Inc. (US) 2008-06-18 EP disclosed