SCHEMBL9846147

SCHEMBL9846147

Cc1nc(OCc2ccccc2)c(C=Cc2nc3ccccc3o2)cc1C(N)=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
HSP90AA1 P07900 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
APP P05067 1/20 0.37
KDM4E B2RXH2 2/20 0.36
EDNRA P25101 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9846142 1.00 MEN1 (0.41) MEN1KMT2AHSP90AA1L3MBTL1NPC1
SCHEMBL9846252 0.88 L3MBTL1 (0.40) MEN1KMT2AHSP90AA1L3MBTL1NPC1
SCHEMBL9846253 0.88 L3MBTL1 (0.40) MEN1KMT2AHSP90AA1L3MBTL1NPC1
SCHEMBL9336639 0.84 L3MBTL1 (0.43) MEN1KMT2AL3MBTL1NPC1RAB9A
SCHEMBL9338293 0.84 L3MBTL1 (0.43) MEN1KMT2AL3MBTL1NPC1RAB9A
SCHEMBL9585229 0.82 L3MBTL1 (0.40) MEN1KMT2AL3MBTL1NPC1RAB9A
SCHEMBL9585232 0.82 L3MBTL1 (0.40) MEN1KMT2AL3MBTL1NPC1RAB9A
SCHEMBL9846237 0.81 L3MBTL1 (0.41) L3MBTL1ATP4AATP4BCNR1GAA
SCHEMBL9846231 0.81 L3MBTL1 (0.41) L3MBTL1ATP4AATP4BCNR1GAA
SCHEMBL9846140 0.80 L3MBTL1 (0.40) L3MBTL1ATP4AATP4BUTRNSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462800-A2 Inhibitors of HIV reverse transcriptase MERCK & CO. INC. (US) 1991-12-27 EP disclosed