Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PRF1 | P14222 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.35 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846166 | 1.00 | APP (0.42) | APPCYP2A6PRF1MAPTMAPK1 | |
| SCHEMBL9265244 | 0.79 | APP (0.44) | APPMAPTNPC1RAB9A | |
| SCHEMBL9846329 | 0.74 | CYP2C19 (0.39) | MAPTNPC1MAOBMAOAALDH1A1 | |
| SCHEMBL9846222 | 0.72 | SMN1; SMN2 (0.41) | MAPTMAPK1MAOBMAOASIRT1 | |
| SCHEMBL9431734 | 0.71 | NR1H3 (0.33) | MAPTMAPK1NPC1RAB9AGAA | |
| SCHEMBL9431737 | 0.71 | NR1H3 (0.33) | MAPTMAPK1NPC1RAB9AGAA | |
| SCHEMBL22867594 | 0.66 | DPYD (0.44) | MAPTNPC1GAALMNAKDM4E | |
| SCHEMBL9846194 | 0.66 | PDE3B (0.36) | MAPK1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL9846195 | 0.66 | PDE3B (0.36) | MAPK1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL1706326 | 0.66 | CYP2A6 (0.60) | APPCYP2A6MAPTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |