Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 12/20 | 0.40 |
| ▸ | ATP4B | P51164 | 12/20 | 0.40 |
| ▸ | UTRN | P46939 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846166 | 0.79 | APP (0.42) | APPNPC1RAB9AMAPT | |
| SCHEMBL9846162 | 0.79 | APP (0.42) | APPNPC1RAB9AMAPT | |
| SCHEMBL5573693 | 0.74 | MAPT (0.54) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL9336647 | 0.73 | ATP4A (0.41) | APPHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9432422 | 0.72 | ELANE (0.48) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL5573692 | 0.72 | MAPT (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9846329 | 0.72 | CYP2C19 (0.39) | MEN1NPC1KMT2AMAPT | |
| SCHEMBL9338293 | 0.72 | L3MBTL1 (0.43) | MEN1NPC1RAB9AKMT2AATP4A | |
| SCHEMBL9336639 | 0.72 | L3MBTL1 (0.43) | MEN1NPC1RAB9AKMT2AATP4A | |
| SCHEMBL6421503 | 0.71 | SNCA (0.64) | APPHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387512-A | Incubating the compound 3-(2-benzoxazol-2-yl-ethyl)-5-ethyl-6-methyl-2-(1H)-pyridinone with liver tissue, oxidation to form a hydroxy group attenching ethyl branch | MERCK & CO. INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5308854-A | 2-benzoxazolylalkyl substituted pyridin-2(1H)(thi)ones; AIDS | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| US-5202243-A | Biosynthetic hydroxylation yields polymerase inhibitors | MERCK & CO., INC. (US) | 1993-04-13 | — | — | US | disclosed |
| US-5185251-A | Treatment of HIV and AIDS | MERCK & CO., INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0484071-A2 | Synergism of HIV reverse transcriptase inhibitors | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0462808-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |