Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573693 | 0.78 | MAPT (0.54) | SMN1; SMN2GAALOXL2KDM4EHTT | |
| SCHEMBL9846102 | 0.73 | GRIN2D (0.36) | SMN1; SMN2GAAKDM4EHTTALDH1A1 | |
| SCHEMBL9278111 | 0.73 | PIK3CD (0.44) | SMN1; SMN2GAAKDM4EMAPK1HTT | |
| SCHEMBL9846162 | 0.72 | APP (0.42) | SMN1; SMN2GAAKDM4EMAPK1HTT | |
| SCHEMBL9846166 | 0.72 | APP (0.42) | SMN1; SMN2GAAKDM4EMAPK1HTT | |
| SCHEMBL9846223 | 0.72 | CYP2C19 (0.45) | MAPTALDH1A1GLAL3MBTL1 | |
| SCHEMBL9846133 | 0.72 | PIK3CD (0.42) | KDM4EMAPTALDH1A1HPGDTSHR | |
| SCHEMBL9846224 | 0.72 | PARP1 (0.37) | SMN1; SMN2KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL6013090 | 0.70 | LOXL2 (0.60) | SMN1; SMN2LOXL2AGXTMAOBMAOA | |
| SCHEMBL31499129 | 0.70 | LOXL2 (0.64) | SMN1; SMN2LOXL2KDM4EAGXTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |