Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846195 | 1.00 | PDE3B (0.36) | PDE3BPDE3AHCAR2TYMSPDE10A | |
| SCHEMBL9846206 | 0.78 | PDE3B (0.40) | PDE3BPDE3AHCAR2PDE10AALDH1A1 | |
| SCHEMBL9680874 | 0.78 | CDK5 (0.39) | PDE3BPDE3AHCAR2PDE10AMEN1 | |
| SCHEMBL9680870 | 0.78 | CDK5 (0.39) | PDE3BPDE3AHCAR2PDE10AMEN1 | |
| SCHEMBL11894731 | 0.75 | PDE3B (0.35) | PDE3BPDE3AHCAR2 | |
| SCHEMBL9267418 | 0.75 | ALDH1A1 (0.39) | LMNAALDH1A1KDM4E | |
| SCHEMBL9846217 | 0.74 | PDE3B (0.37) | PDE3BPDE3AHCAR2PDE10AALDH1A1 | |
| SCHEMBL9333881 | 0.73 | MAPT (0.35) | PDE3BPDE3AHCAR2LMNAALDH1A1 | |
| SCHEMBL9431796 | 0.73 | ALDH1A1 (0.43) | LMNAALDH1A1RAB9AMAPK1 | |
| SCHEMBL9431804 | 0.73 | ALDH1A1 (0.43) | LMNAALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |