Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681336 | 0.84 | HCAR2 (0.34) | PDE3BPDE3AALDH1A1HCAR2KDM4E | |
| SCHEMBL9846217 | 0.82 | PDE3B (0.37) | PDE3BPDE3AALDH1A1HCAR2KDM4E | |
| SCHEMBL9333881 | 0.81 | MAPT (0.35) | PDE3BPDE3AALDH1A1HCAR2KDM4E | |
| SCHEMBL9846194 | 0.78 | PDE3B (0.36) | PDE3BPDE3AALDH1A1HCAR2KDM4E | |
| SCHEMBL9846195 | 0.78 | PDE3B (0.36) | PDE3BPDE3AALDH1A1HCAR2KDM4E | |
| SCHEMBL11894731 | 0.77 | PDE3B (0.35) | PDE3BPDE3AHCAR2 | |
| SCHEMBL9432058 | 0.76 | TAAR1 (0.50) | — | |
| SCHEMBL9246249 | 0.75 | MAPT (0.32) | PDE3BPDE3AKDM4EMAPT | |
| SCHEMBL9432009 | 0.72 | CD274 (0.38) | KDM4EPDE10A | |
| SCHEMBL9272505 | 0.72 | PDE4A (0.40) | ALDH1A1KDM4ETSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |