SCHEMBL9847682

SCHEMBL9847682

CC1=CC(c2cccc([N+](=O)[O-])c2)C([N+](=O)[O-])=C(C)N1C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 2/20 0.41
CACNA1D Q01668 2/20 0.41
CACNA1S Q13698 2/20 0.41
CACNA1C Q13936 2/20 0.41
ADORA3 P0DMS8 1/20 0.41
LMNA P02545 3/20 0.40
ATM Q13315 1/20 0.40
ALDH1A1 P00352 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PDE1C Q14123 1/20 0.40
POLB P06746 1/20 0.40
SLC9A1 P19634 1/20 0.40
TP53 P04637 1/20 0.40
TSHR P16473 2/20 0.39
ACHE P22303 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
NFKB1 P19838 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9847685 0.80 CACNA1F (0.40) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9847680 0.78 LMNA (0.40) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9827844 0.77 CACNA1C (0.43) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL27671464 0.73 CACNA1F (0.42) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL5537883 0.71 LMNA (0.41) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL2781022 0.71 CACNA1C (0.48) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9433626 0.70 KDM4E (0.41) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9668516 0.70 LMNA (0.44) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10469171 0.70 CYP1A2 (0.58) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7420768 0.69 CACNA1F (0.54) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0432751-A2 Isomers of 1-azabicyclo[2.2.2]oct-3-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitropyridine-3-carboxylate MARION MERRELL DOW INC. (US) 1991-06-19 EP disclosed
US-4975437-A Cardiotonic agent MARION LABORATORIES, INC. (US) 1990-12-04 US disclosed