Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 12/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096807 | 0.81 | AGTR1 (0.46) | AGTR1AGTR2TBXA2RMEN1KMT2A | |
| SCHEMBL5109530 | 0.81 | AGTR1 (0.48) | AGTR1AGTR2TBXA2RMEN1KMT2A | |
| SCHEMBL1520801 | 0.81 | KMT2A (0.64) | RECQLMEN1KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL5929370 | 0.80 | AGTR1 (0.47) | AGTR1AGTR2TBXA2RMEN1KMT2A | |
| SCHEMBL14266729 | 0.78 | AGTR1 (0.48) | AGTR1AGTR2TBXA2RRECQLMEN1 | |
| SCHEMBL22965270 | 0.71 | TBXA2R (0.50) | AGTR1AGTR2TBXA2RKMT2AKDM4E | |
| SCHEMBL7447330 | 0.70 | AGTR1 (0.48) | AGTR1AGTR2MEN1KMT2AKDM4E | |
| SCHEMBL5107769 | 0.70 | TBXA2R (0.48) | TBXA2R | |
| SCHEMBL12466547 | 0.70 | ALDH1A1 (0.66) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3065442 | 0.69 | AGTR1 (0.39) | AGTR1AGTR2TBXA2RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |