Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847986 | 1.00 | THRB (0.46) | THRBTHRAACHEUSP2KDM4E | |
| SCHEMBL7302384 | 0.87 | HTT (0.46) | THRBTHRAUSP2KDM4EPKM | |
| SCHEMBL9847959 | 0.84 | SLC7A5 (0.45) | THRBTHRAUSP2KDM4EPKM | |
| SCHEMBL21803856 | 0.83 | THRA (0.47) | THRBTHRAUSP2PKMALOX15 | |
| SCHEMBL16163724 | 0.82 | PTPN1 (0.49) | THRBTHRAUSP2KDM4EPKM | |
| SCHEMBL668470 | 0.80 | USP2 (0.50) | THRBUSP2KDM4EPKMLMNA | |
| SCHEMBL22645606 | 0.80 | SLC7A5 (0.61) | ACHEUSP2KDM4EPKMLMNA | |
| SCHEMBL450849 | 0.80 | SLC7A5 (0.61) | ACHEUSP2KDM4EPKMLMNA | |
| SCHEMBL29351668 | 0.80 | USP2 (0.50) | THRBUSP2KDM4EPKMLMNA | |
| SCHEMBL668469 | 0.80 | USP2 (0.50) | THRBUSP2KDM4EPKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | disclosed |