Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20397701 | 0.87 | MEN1 (0.43) | HTTMEN1KMT2APOLBCYP3A4 | |
| SCHEMBL9847992 | 0.87 | THRB (0.46) | THRBUSP2MEN1KMT2APOLB | |
| SCHEMBL9847986 | 0.87 | THRB (0.46) | THRBUSP2MEN1KMT2APOLB | |
| SCHEMBL13957558 | 0.85 | HSD17B10 (0.45) | THRBUSP2MEN1KMT2APOLB | |
| SCHEMBL29519833 | 0.85 | HSD17B10 (0.49) | THRBUSP2MEN1KMT2APOLB | |
| SCHEMBL21803856 | 0.84 | THRA (0.47) | THRBUSP2MEN1KMT2ARGS12 | |
| Hydrochloric Acid SCHEMBL8862614 | 0.84 | HSD17B10 (0.48) | USP2MEN1KMT2ARGS12CYP3A4 | |
| SCHEMBL7997958 | 0.84 | USP2 (0.44) | THRBUSP2MEN1KMT2APOLB | |
| SCHEMBL1571537 | 0.84 | PCNA (0.51) | THRBUSP2MEN1KMT2ARGS12 | |
| SCHEMBL1571535 | 0.84 | PCNA (0.51) | THRBUSP2MEN1KMT2ARGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |