Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 9/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239786 | 0.85 | TSHR (0.46) | TSHRMAPK1VCAM1CYP3A4ALDH1A1 | |
| SCHEMBL6811567 | 0.81 | — | — | |
| SCHEMBL909526 | 0.80 | TSHR (0.44) | TSHRMAPK1VCAM1CYP3A4ALDH1A1 | |
| SCHEMBL15063757 | 0.80 | TSHR (0.46) | TSHRCYP3A4ALDH1A1TDP1HPGD | |
| SCHEMBL6282528 | 0.78 | TSHR (0.42) | TSHRMAPK1VCAM1CYP3A4ALDH1A1 | |
| SCHEMBL6255476 | 0.77 | ALDH1A1 (0.49) | TSHRMAPK1VCAM1CYP3A4ALDH1A1 | |
| SCHEMBL28847435 | 0.77 | TSHR (0.52) | TSHRCYP3A4ALDH1A1TDP1ALOX15 | |
| SCHEMBL15063896 | 0.76 | MAPT (0.43) | TSHRCYP3A4ALDH1A1TDP1HPGD | |
| SCHEMBL13836301 | 0.73 | TDP1 (0.46) | TSHRVCAM1CYP3A4ALDH1A1TDP1 | |
| SCHEMBL21000996 | 0.73 | TSHR (0.47) | TSHRCYP3A4ALDH1A1TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164018-B1 | CHROMOGENIC 4,4-DIARYL-DIHYDROQUINAZOLONES, THEIR PREPARATION AND USE | BAYER AG (DE) | 1990-10-31 | — | — | EP | claimed |
| EP-0201194-B1 | DIABROTICA LARVICIDAL AGENTS | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | claimed |
| US-4695633-A | Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and their use | BAYER AKTIENGESELLSCHAFT (DE) | 1987-09-22 | — | — | US | claimed |
| EP-0201194-A2 | Diabrotica larvicidal agents | ELI LILLY AND COMPANY (US) | 1986-11-12 | — | — | EP | claimed |
| CN-86102202-A | The preparation method of the chrysomelid genus of bar larva agent for killing | — | 1986-10-01 | — | — | CN | claimed |
| EP-0164018-A2 | Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and use | BAYER AG (DE) | 1985-12-11 | — | — | EP | claimed |
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |
| CN-103987698-B | 2-phenylaminopyrimidine derivatives as kinase LRRK2 modulators for the treatment of Parkinson's disease | HOFFMAN-LA ROCHE LTD. (CH) | 2016-04-20 | — | — | CN | disclosed |
| CN-103987698-A | 2-Phenylaminopyrimidine derivatives as kinase LRRK2 modulators for the treatment of Parkinson's disease | HOFFMANN LA ROCHE | 2014-08-13 | — | — | CN | disclosed |
| CN-102304075-A | Inhibitors of viral replication | INTERMUNE INC | 2012-01-04 | — | — | CN | disclosed |
| CN-101384591-A | Antiviral compounds | ABBOTT LAB (US) | 2009-03-11 | — | — | CN | disclosed |
| CN-101304976-A | Inhibitors of viral replication | INTERMUNE INC (US) | 2008-11-12 | — | — | CN | disclosed |
| CN-1012786-B | The chrysomelid genus of bar kills young agent | LILLY CO ELI (US) | 1991-06-12 | — | — | CN | disclosed |
| EP-0201194-A2 | Diabrotica larvicidal agents | ELI LILLY AND COMPANY (US) | 1986-11-12 | — | — | EP | disclosed |
| CN-86102202-A | The preparation method of the chrysomelid genus of bar larva agent for killing | — | 1986-10-01 | — | — | CN | disclosed |
| CN-86102202-A | The preparation method of the chrysomelid genus of bar larva agent for killing | — | 1986-10-01 | — | — | CN | disclosed |
| EP-0187329-A1 | Chromogenic 3,1-benzoxazines | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |
| EP-0180813-A1 | Chromogenic 4,4-diaryldihydrochinazolones, their preparation and use | BAYER AG (DE) | 1986-05-14 | — | — | EP | disclosed |
| EP-0179378-A1 | Chromogenic 4,4-diaryl-2-oxobenzo-3,1-oxazines, their preparation and use | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0164018-A2 | Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and use | BAYER AG (DE) | 1985-12-11 | — | — | EP | disclosed |