Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25023264 | 0.91 | PLA2G2A (0.43) | PLA2G2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL10687782 | 0.84 | POLB (0.49) | PLA2G2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3489028 | 0.83 | S1PR1 (0.41) | PLA2G2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL25611008 | 0.82 | PIK3CD (0.56) | PLA2G2AALDH1A1HPGDTHRBL3MBTL1 | |
| SCHEMBL15244580 | 0.82 | NPC1 (0.40) | PLA2G2AALDH1A1HPGDTHRBL3MBTL1 | |
| SCHEMBL21592368 | 0.82 | POLB (0.39) | PLA2G2ASLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL13400528 | 0.82 | LPAR3 (0.42) | PLA2G2ASLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL21792622 | 0.81 | SLC6A2 (0.36) | PLA2G2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8773320 | 0.80 | GNAI3 (0.42) | DRD3DRD2DRD4CHRM2CHRM4 | |
| SCHEMBL19604800 | 0.80 | POLB (0.38) | PLA2G2ASLC6A2SLC6A4SLC6A3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421794-A2 | Preparation of piperazinones for use as sulfur dioxide absorbents | THE DOW CHEMICAL COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| US-4980471-A | Preparation of piperazinones for use as sulfur dioxide absorbents | THE DOW CHEMICAL COMPANY (US) | 1990-12-25 | — | — | US | disclosed |
| US-4767860-A | Preparation of N-substituted piperazinones | THE DOW CHEMICAL COMPANY (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0264261-A2 | Preparation of N-substituted piperazinones | THE DOW CHEMICAL COMPANY (US) | 1988-04-20 | — | — | EP | disclosed |