Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 2/20 | 0.38 |
| ▸ | PTAFR | P25105 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quazepam SCHEMBL29504 | 0.87 | OPRK1 (0.58) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| Quazepam SCHEMBL29534458 | 0.87 | OPRK1 (0.58) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| Quazepam SCHEMBL21647120 | 0.86 | OPRK1 (0.57) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| SCHEMBL9757526 | 0.76 | OPRK1 (0.59) | OPRK1NR1I2ADORA3OPRM1DRD3 | |
| Quazepam SCHEMBL3177949 | 0.75 | OPRK1 (0.45) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| Quazepam SCHEMBL1181404 | 0.74 | OPRK1 (0.66) | OPRK1NR1I2ADORA3OPRM1DRD3 | |
| SCHEMBL5379874 | 0.73 | OPRK1 (0.77) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| SCHEMBL13531318 | 0.72 | OPRK1 (0.62) | OPRK1NR1I2ADORA3OPRM1CHRM1 | |
| SCHEMBL3249926 | 0.70 | NR1I2 (0.74) | OPRK1NR1I2ADORA3OPRM1KCNH2 | |
| SCHEMBL6004989 | 0.70 | GABRP (0.44) | KCNH2CCKBRGABRA1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428272-A2 | Trifluorobenzodiazepine compounds for use in therapy by intraoral administration | Ellinwood, Everett Hews (US) | 1991-05-22 | — | — | EP | disclosed |