Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 4/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028981 | 0.85 | PSEN1 (0.34) | PSEN1 | |
| SCHEMBL5957804 | 0.83 | PSEN1 (0.40) | PTGER1PSEN1 | |
| SCHEMBL8308667 | 0.82 | PSEN1 (0.45) | PSEN1 | |
| SCHEMBL9028284 | 0.81 | MAOB (0.34) | PSEN1ALDH1A1 | |
| SCHEMBL9027411 | 0.79 | — | — | |
| SCHEMBL9027417 | 0.79 | — | — | |
| SCHEMBL9029391 | 0.79 | PPARG (0.34) | FFAR1PSEN1 | |
| SCHEMBL9028233 | 0.78 | LMNA (0.36) | PSEN1 | |
| SCHEMBL9028462 | 0.78 | LTA4H (0.40) | PTGER4PTGER3PTGER2PTGER1PSEN1 | |
| SCHEMBL7796530 | 0.77 | PSEN1 (0.41) | PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |